Life Music: Improvisation on Genetic Themes

M. A. Clark and John Dunn*
The proteins represented on this CD were selected as examples of four broad structural categories: predominantly alpha-helix, predominantly beta-strands, mixed alpha/beta, and repetitive fibrillar proteins. This CD can be obtained from Algorithmic Arts.

Proteins on the Life Music CD

Alpha Beta Alpha/Beta Repetitive
Protein Duration Brief description
*Beta-globin 5:42 A contemplative setting of the beta-globin sequences of four mammals: human, whale, bat and echidna. 
Calmodulin  2:55 A bouncy alpha dance tune emphasizes this modular protein's four calcium-binding sites
Gamma lens crystallin 2:54 Another four-module protein, emphasizing similarities in the beta-regions from several species.
Alcohol Dehydrogenase 5:03 Multiple repeated amino acids in this sequence produce a tune with a rowdy jig-like rhythm. 
Lysozyme C
(setting I)
3:43 This piece visits the sequences of four mammals, as they sing their tune solo, and in duets and trios.
*Lysozyme C
(setting II)
7:13 In this piece human lysozyme stars, but is supported by mouse, green monkey and echidna in an inventive series of instrumental treatments. 
Triose Phosphate Isomerase 6:36 A piece in which the complex folding pattern of the TIM barrel emerges one feature at a time.
Spidroin 3:34 A spinning song, in which a 13-residue repeat of spider silk returns again and again throughout the piece.
*Collagen  13:56 A musical journey through a large and complex protein, divided into five musical landscapes. 

These pieces were all created using software from Algorithmic Arts. Audio files on this page may be downloaded for nonprofit use. If you use any of the music on your own web site, or in any other presentation format, please include a link to this page.